Decoding the Problem:
Why is there a shortage of Livers?
We create the best possible environment for a liver outside the human body.
Organ Recovery
The only perfusion system capable of extending liver preservation to up to seven days. Preclinical data suggest that prolonged perfusion maintains viability and supports organ recovery, unlocking new possibilities for long-term organ preservation and improved transplant outcomes.
Organ Assessment
An ideal physiological environment allows for prolonged continuous / real-time assessment of organ viability.
Ease of Use
An advanced control system ensuring a high level of automation with minimal need of supervision.
Benefits
- Longer time for viability assessment
- Unmatched Flexibility
- Expansion of organ pool as suggested by preclinical data
Features
- Advanced perfusion technology
- Highly automated system
- Innovative research and development capabilities
Please be advised that for ethical reasons, no real blood was utilized in the production of this video. As a result, the color depicted may differ from real blood.
- Defatting of Human Livers During Long-Term ex situ Normothermic Perfusion: Novel Strategy to Rescue Discarded Organs for Transplantation
Sousa Da Silva RX, Bautista Borrego L, Lenggenhager D, Huwyler F, Binz J, Mancina L, Breuer E, Wernlé K, Hefti M, Mueller M, Cunningham L, De Oliveira ML, Petrowsky H, Weber A, Dutkowski P, Hoffmann W, Gupta A, Tibbitt MW, Humar B, Clavien PA. Ann Surg. 2023 Nov - An integrated perfusion machine preserves injured human livers for 1 week.
Eshmuminov D, Becker D, Bautista Borrego L, Hefti M, Schuler MJ, Hagedorn C, Muller X, Mueller M, Onder C, Graf R, Weber A, Dutkowski P, Rudolf von Rohr P, Clavien PA. Nat Biotechnol. 2020 - Transplantation of a human liver following 3 days of ex situ normothermic preservation
Clavien PA, Dutkowski P, Mueller M, Eshmuminov D, Bautista Borrego L, Weber A, Muellhaupt B, Sousa Da Silva RX, Burg BR, Rudolf von Rohr P, Schuler MJ, Becker D, Hefti M, Tibbitt MW. Nat Biotechnol. 2022 Nov - Long-term Normothermic Machine Preservation of Partial Livers: First Experience With 21 Human Hemi-livers
Mueller M, Hefti M, Eshmuminov D, Schuler MJ, Sousa Da Silva RX, Petrowsky H, De Oliveira ML, Oberkofler CE, Hagedorn C, Mancina L, Weber A, Burg B, Tibbitt MW, Rudolf von Rohr P, Dutkowski P, Becker D, Bautista Borrego L, Clavien PA. Ann Surg. 2021 Nov - Long-term dynamic ex vivo organ preservation.
Eshmuminov D, Clavien PA. Nat Rev Gastroenterol Hepatol. 2023 May - Observations and findings during the development of a subnormothermic/normothermic long-term ex vivo liver perfusion machine.
Schuler MJ, Becker D, Mueller M, Bautista Borrego L, Mancina L, Huwyler F, Binz J, Hagedorn C, Schär B, Gygax E, Weisskopf M, Sousa Da Silva RX, Antunes Crisóstomo JM, Dutkowski P, Rudolf von Rohr P, Clavien PA, Tibbitt MW, Eshmuminov D, Hefti M. Artif Organs. 2023 Feb - Synthesis of coagulation factors during long-term ex situ liver perfusion.
Eshmuminov D, Hefti M, Mueller M, Schuler MJ, Bautista Borrego L, Schneider MA, Koch K, Weisskopf M, Tibbitt MW, Dutkowski P, Rudolf von Rohr P, Studt JD, Becker D, Clavien PA. Artif Organs. 2022 Feb - Sources and prevention of graft infection during long-term ex situ liver perfusion.
Eshmuminov D, Mueller M, Brugger SD, Bautista Borrego L, Becker D, Hefti M, Hagedorn C, Duskabilova M, Tibbitt MW, Dutkowski P, Rudolf von Rohr P, Schuler MJ, Mueller NJ, Clavien PA. Transpl Infect Dis. 2021 Aug - FDG-PET/CT: novel method for viability assessment of livers perfused ex vivo.
Orita E, Becker D, Mueller M, Hefti M, Schuler MJ, Bautista Borrego L, Dutkowski P, Zeimpekis K, Treyer V, Kaufmann PA, Eshmuminov D, Clavien PA, Huellner MW. Nucl Med Commun. 2021 Jul - Bile formation in long-term ex situ perfused livers.
Eshmuminov D, Schuler MJ, Becker D, Bautista Borrego L, Mueller M, Hagedorn C, Häusler S, Steiger J, Tibbitt MW, Dutkowski P, Rudolf von Rohr P, Stieger B, Hefti M, Clavien PA. Surgery. 2021 Apr - Hyperoxia in portal vein causes enhanced vasoconstriction in arterial vascular bed.
Eshmuminov D, Becker D, Hefti ML, Mueller M, Hagedorn C, Dutkowski P, Rudolf von Rohr P, Halbe M, Segerer S, Tibbitt MW, Bautista Borrego L, Schuler MJ, Clavien PA. Sci Rep. 2020 Dec - Automated Insulin Delivery – Continuous Blood Glucose Control During Ex Situ Liver Perfusion.
Becker D, Eshmuminov D, Keller R, Mueller M, Bautista Borrego L, Hagedorn C, Duskabilova M, Tibbitt MW, Onder C, Clavien PA, Rudolf von Rohr P, Schuler MJ, Hefti M. IEEE Trans Biomed Eng. 2021 Apr - Model Assisted Analysis of the Hepatic Arterial Buffer Response During Ex Vivo Porcine Liver Perfusion.
Becker D, Hefti M, Schuler MJ, Borrego LB, Hagedorn C, Muller X, Graf R, Dutkowski P, Tibbitt MW, Onder C, Clavien PA, Eshmuminov D, von Rohr PR. IEEE Trans Biomed Eng. 2020 Mar - Perfusion settings and additives in liver normothermic machine perfusion with red blood cells as oxygen carrier. A systematic review of human and porcine perfusion protocols.
Eshmuminov D, Leoni F, Schneider MA, Becker D, Muller X, Onder C, Hefti M, Schuler MJ, Dutkowski P, Graf R, Rudolf von Rohr P, Clavien PA, Bautista Borrego L. Transpl Int. 2018 Jun - Machine perfusion in liver transplantation.
Sousa Da Silva RX, Weber A, Dutkowski P, Clavien PA. Hepatology. 2022 Nov
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